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    Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan


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    Reference Type: Journal Article

    Record Number: 35

    Author: S. Firasat, S. Khaliq, A. Mohyuddin, M. Papaioannou, C. Tyler-Smith, P. A. Underhill and Q. Ayub

    Year: 2007

    Title: Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan

    Journal: Eur J Hum Genet

    Volume: 15

    Issue: 1

    Pages: 121-6

    Epub Date: 2006/10/19

    Date: Jan

    Short Title: Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan

    ISSN: 1018-4813 (Print)

    DOI: 5201726 [pii], 10.1038/sj.ejhg.5201726,

    Accession Number: 17047675

    Keywords: Cell Line, *Chromosomes, Human, Y, Ethnic Groups/*genetics, Genetics, Population, Greece/ethnology, Haplotypes, Humans, Male, Microsatellite Repeats, Pakistan,

    Abstract: Three Pakistani populations residing in northern Pakistan, the Burusho, Kalash and Pathan claim descent from Greek soldiers associated with Alexander's invasion of southwest Asia. Earlier studies have excluded a substantial Greek genetic input into these populations, but left open the question of a smaller contribution. We have now typed 90 binary polymorphisms and 16 multiallelic, short-tandem-repeat (STR) loci mapping to the male-specific portion of the human Y chromosome in 952 males, including 77 Greeks in order to re-investigate this question. In pairwise comparisons between the Greeks and the three Pakistani populations using genetic distance measures sensitive to recent events, the lowest distances were observed between the Greeks and the Pathans. Clade E3b1 lineages, which were frequent in the Greeks but not in Pakistan, were nevertheless observed in two Pathan individuals, one of whom shared a 16 Y-STR haplotype with the Greeks. The worldwide distribution of a shortened (9 Y-STR) version of this haplotype, determined from database information, was concentrated in Macedonia and Greece, suggesting an origin there. Although based on only a few unrelated descendants, this provides strong evidence for a European origin for a small proportion of the Pathan Y chromosomes.

    Notes: Firasat, Sadaf, Khaliq, Shagufta, Mohyuddin, Aisha, Papaioannou, Myrto, Tyler-Smith, Chris, Underhill, Peter A, Ayub, Qasim, 077009/Wellcome Trust/United Kingdom, Wellcome Trust/United Kingdom, Research Support, Non-U.S. Gov't, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2007 Jan;15(1):121-6. Epub 2006 Oct 18.,

    Author Address: Biomedical and Genetic Engineering Division, Dr. AQ Khan Research Laboratories, Islamabad, Pakistan.

    Language: eng