Работает база данных...

    • Main Page
    • SOURCES: Papers on Y сhromosomal variation

    The Himalayas as a directional barrier to gene flow

    У вас нет прав на скачивание файла
    Forgot your password?

    Reference Type: Journal Article

    Record Number: 40

    Author: T. Gayden, A. M. Cadenas, M. Regueiro, N. B. Singh, L. A. Zhivotovsky, P. A. Underhill, L. L. Cavalli-Sforza and R. J. Herrera

    Year: 2007

    Title: The Himalayas as a directional barrier to gene flow

    Journal: Am J Hum Genet

    Volume: 80

    Issue: 5

    Pages: 884-94

    Epub Date: 2007/04/17

    Date: May

    Short Title: The Himalayas as a directional barrier to gene flow

    ISSN: 0002-9297 (Print)

    DOI: S0002-9297(07)60944-6 [pii], 10.1086/516757,

    Accession Number: 17436243

    Keywords: Asia/ethnology, Chromosomes, Human, Y/*genetics, Ethnic Groups/genetics, *Gene Flow, Genetic Variation, Genetics, Population, Geography, Haplotypes, Humans, India/ethnology, Male, Microsatellite Repeats, Nepal, Phylogeny, Polymorphism, Single Nucleotide, Tibet, Time Factors,

    Abstract: High-resolution Y-chromosome haplogroup analyses coupled with Y-short tandem repeat (STR) haplotypes were used to (1) investigate the genetic affinities of three populations from Nepal--including Newar, Tamang, and people from cosmopolitan Kathmandu (referred to as "Kathmandu" subsequently)--as well as a collection from Tibet and (2) evaluate whether the Himalayan mountain range represents a geographic barrier for gene flow between the Tibetan plateau and the South Asian subcontinent. The results suggest that the Tibetans and Nepalese are in part descendants of Tibeto-Burman-speaking groups originating from Northeast Asia. All four populations are represented predominantly by haplogroup O3a5-M134-derived chromosomes, whose Y-STR-based age (+/-SE) was estimated at 8.1+/-2.9 thousand years ago (KYA), more recent than its Southeast Asian counterpart. The most pronounced difference between the two regions is reflected in the opposing high-frequency distributions of haplogroups D in Tibet and R in Nepal. With the exception of Tamang, both Newar and Kathmandu exhibit considerable similarities to the Indian Y-haplogroup distribution, particularly in their haplogroup R and H composition. These results indicate gene flow from the Indian subcontinent and, in the case of haplogroup R, from Eurasia as well, a conclusion that is also supported by the admixture analysis. In contrast, whereas haplogroup D is completely absent in Nepal, it accounts for 50.6% of the Tibetan Y-chromosome gene pool. Coalescent analyses suggest that the expansion of haplogroup D derivatives--namely, D1-M15 and D3-P47 in Tibet--involved two different demographic events (5.1+/-1.8 and 11.3+/-3.7 KYA, respectively) that are more recent than those of D2-M55 representatives common in Japan. Low frequencies, relative to Nepal, of haplogroup J and R lineages in Tibet are also consistent with restricted gene flow from the subcontinent. Yet the presence of haplogroup O3a5-M134 representatives in Nepal indicates that the Himalayas have been permeable to dispersals from the east. These genetic patterns suggest that this cordillera has been a biased bidirectional barrier.

    Notes: Gayden, Tenzin, Cadenas, Alicia M, Regueiro, Maria, Singh, Nanda B, Zhivotovsky, Lev A, Underhill, Peter A, Cavalli-Sforza, Luigi L, Herrera, Rene J, Research Support, Non-U.S. Gov't, United States, American journal of human genetics, Am J Hum Genet. 2007 May;80(5):884-94. Epub 2007 Apr 4.,

    Author Address: Department of Biological Sciences, Florida International University, Miami, FL 33199, USA.

    Language: eng