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    The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages


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    Reference Type: Journal Article

    Record Number: 50

    Author: M. E. Hurles, B. C. Sykes, M. A. Jobling and P. Forster

    Year: 2005

    Title: The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages

    Journal: Am J Hum Genet

    Volume: 76

    Issue: 5

    Pages: 894-901

    Epub Date: 2005/03/29

    Date: May

    Short Title: The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages

    ISSN: 0002-9297 (Print)

    DOI: S0002-9297(07)60736-8 [pii], 10.1086/430051,

    Accession Number: 15793703

    Keywords: Africa/ethnology, African Continental Ancestry Group/*genetics, Asia, Southeastern/ethnology, Asian Continental Ancestry Group/*genetics, *Chromosomes, Human, Y, *DNA, Mitochondrial, Emigration and Immigration, Ethnic Groups, Female, Genetic Variation, Genetics, Population, *Haplotypes, Humans, Language, Madagascar, Male, Mothers, *Phylogeny, Polymorphism, Genetic, Sequence Analysis,

    Abstract: Linguistic and archaeological evidence about the origins of the Malagasy, the indigenous peoples of Madagascar, points to mixed African and Indonesian ancestry. By contrast, genetic evidence about the origins of the Malagasy has hitherto remained partial and imprecise. We defined 26 Y-chromosomal lineages by typing 44 Y-chromosomal polymorphisms in 362 males from four different ethnic groups from Madagascar and 10 potential ancestral populations in Island Southeast Asia and the Pacific. We also compared mitochondrial sequence diversity in the Malagasy with a manually curated database of 19,371 hypervariable segment I sequences, incorporating both published and unpublished data. We could attribute every maternal and paternal lineage found in the Malagasy to a likely geographic origin. Here, we demonstrate approximately equal African and Indonesian contributions to both paternal and maternal Malagasy lineages. The most likely origin of the Asia-derived paternal lineages found in the Malagasy is Borneo. This agrees strikingly with the linguistic evidence that the languages spoken around the Barito River in southern Borneo are the closest extant relatives of Malagasy languages. As a result of their equally balanced admixed ancestry, the Malagasy may represent an ideal population in which to identify loci underlying complex traits of both anthropological and medical interest.

    Notes: Hurles, Matthew E, Sykes, Bryan C, Jobling, Mark A, Forster, Peter, Comparative Study, Research Support, Non-U.S. Gov't, United States, American journal of human genetics, Am J Hum Genet. 2005 May;76(5):894-901. Epub 2005 Mar 25.,

    Author Address: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom. meh@sanger.ac.uk

    Language: eng