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    Paternal population history of East Asia: sources, patterns, and microevolutionary processes

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    Reference Type: Journal Article

    Record Number: 51

    Author: T. Karafet, L. Xu, R. Du, W. Wang, S. Feng, R. S. Wells, A. J. Redd, S. L. Zegura and M. F. Hammer

    Year: 2001

    Title: Paternal population history of East Asia: sources, patterns, and microevolutionary processes

    Journal: Am J Hum Genet

    Volume: 69

    Issue: 3

    Pages: 615-28

    Epub Date: 2001/08/02

    Date: Sep

    Short Title: Paternal population history of East Asia: sources, patterns, and microevolutionary processes

    ISSN: 0002-9297 (Print)

    DOI: S0002-9297(07)61171-9 [pii], 10.1086/323299,

    Accession Number: 11481588

    Keywords: Animals, Far East/ethnology, Genetic Variation, *Genetics, Population, Genotype, Haplotypes, *Hominidae, Humans, Polymorphism, Genetic, *Y Chromosome,

    Abstract: Asia has served as a focal point for human migration during much of the Late Pleistocene and Holocene. Clarification of East Asia's role as a source and/or transit point for human dispersals requires that this region's own settlement history be understood. To this end, we examined variation at 52 polymorphic sites on the nonrecombining portion of the Y chromosome (NRY) in 1,383 unrelated males, representing 25 populations from southern East Asia (SEAS), northern East Asia (NEAS), and central Asia (CAS). The polymorphisms defined 45 global haplogroups, 28 of which were present in these three regions. Although heterozygosity levels were similar in all three regions, the average pairwise difference among haplogroups was noticeably smaller in SEAS. Multidimensional scaling analysis indicated a general separation of SEAS versus NEAS and CAS populations, and analysis of molecular variance produced very different values of Phi(ST) in NEAS and SEAS populations. In spatial autocorrelation analyses, the overall correlogram exhibited a clinal pattern; however, the NEAS populations showed evidence of both isolation by distance and ancient clines, whereas there was no evidence of structure in SEAS populations. Nested cladistic analysis demonstrated that population history events and ongoing demographic processes both contributed to the contrasting patterns of NRY variation in NEAS and SEAS. We conclude that the peopling of East Asia was more complex than earlier models had proposed-that is, a multilayered, multidirectional, and multidisciplinary framework is necessary. For instance, in addition to the previously recognized genetic and dental dispersal signals from SEAS to NEAS populations, CAS has made a significant contribution to the contemporary gene pool of NEAS, and the Sino-Tibetan expansion has left traces of a genetic trail from northern to southern China.

    Notes: Karafet, T, Xu, L, Du, R, Wang, W, Feng, S, Wells, R S, Redd, A J, Zegura, S L, Hammer, M F, GM-53566-06/GM/NIGMS NIH HHS/United States, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., United States, American journal of human genetics, Am J Hum Genet. 2001 Sep;69(3):615-28. Epub 2001 Jul 30.,

    Author Address: Laboratory of Molecular Systematics and Evolution, University of Arizona, Tucson, AZ 85721, USA.

    Language: eng