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    Y-chromosomal short tandem repeat haplotypes in southern Croatian male population defined by 17 loci


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    Reference Type: Journal Article

    Record Number: 76

    Author: J. Ljubkovic, A. Stipisic, D. Sutlovic, M. Definis-Gojanovic, K. Bucan and S. Andelinovic

    Year: 2008

    Title: Y-chromosomal short tandem repeat haplotypes in southern Croatian male population defined by 17 loci

    Journal: Croat Med J

    Volume: 49

    Issue: 2

    Pages: 201-6

    Epub Date: 2008/05/08

    Date: Apr

    Short Title: Y-chromosomal short tandem repeat haplotypes in southern Croatian male population defined by 17 loci

    ISSN: 1332-8166 (Electronic)

    Accession Number: 18461675

    Keywords: Chromosomes, Human, Y/*genetics, Croatia, Gene Frequency, Genetics, Population, Genotype, Haplotypes/*genetics, Humans, Male, Microsatellite Repeats/*genetics, Polymorphism, Genetic/*genetics,

    Abstract: AIM: To define the Y-chromosome genetic structure in a sample of men from southern Croatia. METHODS: Blood samples were collected from 166 unrelated healthy men from southern Croatia at the Department of Forensic Medicine and Biochemical Laboratory of University Hospital Split between 2004 and 2007. Genomic DNA was extracted using the standard procedures. Seventeen Y-chromosome short tandem repeat (Y-STR) polymorphic loci (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385, DYS393, DYS391, DYS439, DYS635, DYS392, GATAH4, DYS437, DYS438, and DYS448) were analyzed using AmpFlSTR Yfiler Polymerase Chain Reaction Amplification Kit. RESULTS: We observed 152 different haplotypes. Total haplotype diversity was 0.997289 and 141 haplotypes (84.49%) were unique. The most common haplotype was shared by only 4 men in the study sample. The locus diversity ranged between 0.21292 for DYS392 and 0.75546 for DYS439 locus. CONCLUSION: The Y-chromosome structure in men from southern Croatia is very diverse. Combination of Y chromosome 17 STR loci may be used as a powerful tool for individual identification and parentage analysis in the southern Croatian male population.

    Notes: Ljubkovic, Jelena, Stipisic, Angela, Sutlovic, Davorka, Definis-Gojanovic, Marija, Bucan, Kajo, Andelinovic, Simun, Research Support, Non-U.S. Gov't, Croatia, Croatian medical journal, Croat Med J. 2008 Apr;49(2):201-6.,

    Author Address: Department of Pathology and Forensic Medicine, Split University Hospital and School of Medicine, Split, Croatia.

    Language: eng