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    In search of the pre- and post-neolithic genetic substrates in Iberia: evidence from Y-chromosome in Pyrenean populations

    Reference Type: Journal Article

    Record Number: 78

    Author: A. M. Lopez-Parra, L. Gusmao, L. Tavares, C. Baeza, A. Amorim, M. S. Mesa, M. J. Prata and E. Arroyo-Pardo

    Year: 2009

    Title: In search of the pre- and post-neolithic genetic substrates in Iberia: evidence from Y-chromosome in Pyrenean populations

    Journal: Ann Hum Genet

    Volume: 73

    Issue: 1

    Pages: 42-53

    Epub Date: 2008/09/23

    Date: Jan

    Short Title: In search of the pre- and post-neolithic genetic substrates in Iberia: evidence from Y-chromosome in Pyrenean populations

    ISSN: 1469-1809 (Electronic)

    DOI: AHG478 [pii], 10.1111/j.1469-1809.2008.00478.x,

    Accession Number: 18803634

    Keywords: Chromosomes, Human, Y/*genetics, European Continental Ancestry Group/classification/ethnology/*genetics, Genetic Variation, Haplotypes, Humans, Male, Phylogeny, Polymorphism, Single Nucleotide,

    Abstract: The male-mediated genetic legacy of the Pyrenean population was assessed through the analysis of 12 Y-STR and 27 Y-SNP loci in a sample of 169 males from 5 main geographical areas in the Spanish Pyrenees: Cinco Villas (Western Pyrenees), Jacetania and Valle de Aran (Central Pyrenees) and Alto Urgel and Cerdana (Eastern Pyrenees). In the Iberian context, the Pyrenean samples present some specificities, being characterizeded by a high proportion of chromosomes R1b1b2-M269 (including the usually uncommon R1b1b2d-SRY(2627) and R1b1b2c-M153 types) or I2a2-M26 and low proportions of other haplogroups. Our results indicate that an old pre-Neolithic substrate is preponderant in populations of the whole Pyrenean fringe. However, AMOVA revealed a high level of substructure within Pyrenean populations, partially explained by drift effects as well as by the signature of an ancient genetic differentiation between Western and Eastern Pyrenees.

    Notes: Lopez-Parra, A M, Gusmao, L, Tavares, L, Baeza, C, Amorim, A, Mesa, M S, Prata, M J, Arroyo-Pardo, E, Research Support, Non-U.S. Gov't, England, Annals of human genetics, Ann Hum Genet. 2009 Jan;73(1):42-53. Epub 2008 Sep 17.,

    Author Address: Departamento de Toxicologia y Legislacion Sanitaria, Facultad de Medicina, Universidad Complutense de Madrid, Spain.

    Language: eng