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    The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations

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    Reference Type: Journal Article

    Record Number: 80

    Author: J. R. Luis, D. J. Rowold, M. Regueiro, B. Caeiro, C. Cinnioglu, C. Roseman, P. A. Underhill, L. L. Cavalli-Sforza and R. J. Herrera

    Year: 2004

    Title: The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations

    Journal: Am J Hum Genet

    Volume: 74

    Issue: 3

    Pages: 532-44

    Epub Date: 2004/02/20

    Date: Mar

    Short Title: The Levant versus the Horn of Africa: evidence for bidirectional corridors of human migrations

    ISSN: 0002-9297 (Print)

    DOI: 10.1086/382286, S0002-9297(07)61870-9 [pii],

    Accession Number: 14973781

    Keywords: Africa, Eastern, African Continental Ancestry Group/*genetics, Benin, Cameroon, Chromosomes, Human, Y/genetics, Egypt, *Emigration and Immigration, Genetic Markers, Humans, Male, Microsatellite Repeats, Oman, Phylogeny,

    Abstract: Paleoanthropological evidence indicates that both the Levantine corridor and the Horn of Africa served, repeatedly, as migratory corridors between Africa and Eurasia. We have begun investigating the roles of these passageways in bidirectional migrations of anatomically modern humans, by analyzing 45 informative biallelic markers as well as 10 microsatellite loci on the nonrecombining region of the Y chromosome (NRY) in 121 and 147 extant males from Oman and northern Egypt, respectively. The present study uncovers three important points concerning these demic movements: (1) The E3b1-M78 and E3b3-M123 lineages, as well as the R1*-M173 lineages, mark gene flow between Egypt and the Levant during the Upper Paleolithic and Mesolithic. (2) In contrast, the Horn of Africa appears to be of minor importance in the human migratory movements between Africa and Eurasia represented by these chromosomes, an observation based on the frequency distributions of E3b*-M35 (no known downstream mutations) and M173. (3) The areal diffusion patterns of G-M201, J-12f2, the derivative M173 haplogroups, and M2 suggest more recent genetic associations between the Middle East and Africa, involving the Levantine corridor and/or Arab slave routes. Affinities to African groups were also evaluated by determining the NRY haplogroup composition in 434 samples from seven sub-Saharan African populations. Oman and Egypt's NRY frequency distributions appear to be much more similar to those of the Middle East than to any sub-Saharan African population, suggesting a much larger Eurasian genetic component. Finally, the overall phylogeographic profile reveals several clinal patterns and genetic partitions that may indicate source, direction, and relative timing of different waves of dispersals and expansions involving these nine populations.

    Notes: Luis, J R, Rowold, D J, Regueiro, M, Caeiro, B, Cinnioglu, C, Roseman, C, Underhill, P A, Cavalli-Sforza, L L, Herrera, R J, GM 08205/GM/NIGMS NIH HHS/United States, GM 61347/GM/NIGMS NIH HHS/United States, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., United States, American journal of human genetics, Am J Hum Genet. 2004 Mar;74(3):532-44. Epub 2004 Feb 17.,

    Author Address: Department of Biological Sciences, Florida International University, Miami, 33199, USA.

    Language: eng