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    Mitochondrial DNA and Y-chromosome variation in the caucasus


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    Reference Type: Journal Article

    Record Number: 102

    Author: I. Nasidze, E. Y. Ling, D. Quinque, I. Dupanloup, R. Cordaux, S. Rychkov, O. Naumova, O. Zhukova, N. Sarraf-Zadegan, G. A. Naderi, S. Asgary, S. Sardas, D. D. Farhud, T. Sarkisian, C. Asadov, A. Kerimov and M. Stoneking

    Year: 2004

    Title: Mitochondrial DNA and Y-chromosome variation in the caucasus

    Journal: Ann Hum Genet

    Volume: 68

    Issue: Pt 3

    Pages: 205-21

    Epub Date: 2004/06/08

    Date: May

    Short Title: Mitochondrial DNA and Y-chromosome variation in the caucasus

    ISSN: 0003-4800 (Print)

    DOI: 10.1046/j.1529-8817.2004.00092.x, AHG092 [pii],

    Accession Number: 15180701

    Keywords: Chromosomes, Human, Y/*genetics, DNA, Mitochondrial/*genetics, Ethnic Groups, European Continental Ancestry Group/*genetics, *Genetic Variation, Genetics, Population, Haplotypes, Humans, Male, Tandem Repeat Sequences,

    Abstract: We have analyzed mtDNA HVI sequences and Y chromosome haplogroups based on 11 binary markers in 371 individuals, from 11 populations in the Caucasus and the neighbouring countries of Turkey and Iran. Y chromosome haplogroup diversity in the Caucasus was almost as high as in Central Asia and the Near East, and significantly higher than in Europe. More than 27% of the variance in Y-haplogroups can be attributed to differences between populations, whereas mtDNA showed much lower heterogeneity between populations (less then 5%), suggesting a strong influence of patrilocal social structure. Several groups from the highland region of the Caucasus exhibited low diversity and high differentiation for either or both genetic systems, reflecting enhanced genetic drift in these small, isolated populations. Overall, the Caucasus groups showed greater similarity with West Asian than with European groups for both genetic systems, although this similarity was much more pronounced for the Y chromosome than for mtDNA, suggesting that male-mediated migrations from West Asia have influenced the genetic structure of Caucasus populations.

    Notes: Nasidze, I, Ling, E Y S, Quinque, D, Dupanloup, I, Cordaux, R, Rychkov, S, Naumova, O, Zhukova, O, Sarraf-Zadegan, N, Naderi, G A, Asgary, S, Sardas, S, Farhud, D D, Sarkisian, T, Asadov, C, Kerimov, A, Stoneking, M, Comparative Study, Research Support, Non-U.S. Gov't, England, Annals of human genetics, Ann Hum Genet. 2004 May;68(Pt 3):205-21.,

    Author Address: Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, Germany. nasidze@eva.mpg.de

    Language: eng