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    Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms


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    Reference Type: Journal Article

    Record Number: 114

    Author: G. Passarino, G. L. Cavalleri, A. A. Lin, L. L. Cavalli-Sforza, A. L. Borresen-Dale and P. A. Underhill

    Year: 2002

    Title: Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms

    Journal: Eur J Hum Genet

    Volume: 10

    Issue: 9

    Pages: 521-9

    Epub Date: 2002/08/13

    Date: Sep

    Short Title: Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms

    ISSN: 1018-4813 (Print)

    DOI: 10.1038/sj.ejhg.5200834,

    Accession Number: 12173029

    Keywords: Chromosome Mapping, *Chromosomes, Human, Y, DNA, Mitochondrial/*genetics, Europe/ethnology, European Continental Ancestry Group/*genetics, Genetic Markers, Geography, Haplotypes, Humans, Male, Norway, *Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid, Restriction Mapping,

    Abstract: The genetic composition of the Norwegian population was investigated by analysing polymorphisms associated with both the mitochondrial DNA (mtDNA) and Y chromosome loci in a sample of 74 Norwegian males. The combination of their uniparental mode of inheritance and the absence of recombination make these haplotypic stretches of DNA the tools of choice in evaluating the different components of a population's gene pool. The sequencing of the Dloop and two diagnostic RFLPs (AluI 7025 and HinfI at 12 308) allowed us to classify the mtDNA molecules in 10 previously described groups. As for the Y chromosome the combination of binary markers and microsatellites allowed us to compare our results to those obtained elsewhere in Europe. Both mtDNA and Y chromosome polymorphisms showed a noticeable genetic affinity between Norwegians and central Europeans, especially Germans. When the phylogeographic analysis of the Y chromosome haplotypes was attempted some interesting clues on the peopling of Norway emerged. Although Y chromosome binary and microsatellite data indicate that 80% of the haplotypes are closely related to Central and western Europeans, the remainder share a unique binary marker (M17) common in eastern Europeans with informative microsatellite haplotypes suggesting a different demographic history. Other minor genetic influences on the Norwegian population from Uralic speakers and Mediterranean populations were also highlighted.

    Notes: Passarino, Giuseppe, Cavalleri, Gianpiero L, Lin, Alice A, Cavalli-Sforza, Luigi Luca, Borresen-Dale, Anne-Lise, Underhill, Peter A, GM28428/GM/NIGMS NIH HHS/United States, GM55273/GM/NIGMS NIH HHS/United States, Research Support, U.S. Gov't, P.H.S., England, European journal of human genetics : EJHG, Eur J Hum Genet. 2002 Sep;10(9):521-9.,

    Author Address: Dipartimento di Biologia Cellulare, Universita della Calabria, Ponte Pietro Bucci c/da Arcavacata, 87030 Rende, Italy. giuseppe.passarino@unical.it

    Language: eng