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    Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers


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    Reference Type: Journal Article

    Record Number: 123

    Author: V. N. Pimenoff, D. Comas, J. U. Palo, G. Vershubsky, A. Kozlov and A. Sajantila

    Year: 2008

    Title: Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers

    Journal: Eur J Hum Genet

    Volume: 16

    Issue: 10

    Pages: 1254-64

    Epub Date: 2008/05/29

    Date: Oct

    Short Title: Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers

    ISSN: 1018-4813 (Print)

    DOI: ejhg2008101 [pii], 10.1038/ejhg.2008.101,

    Accession Number: 18506205

    Keywords: Chromosomes, Human, Y/genetics, DNA, Mitochondrial/genetics, Ethnic Groups/*genetics, *Gene Pool, Genealogy and Heraldry, Genetic Markers, Genetic Variation, Haplotypes, Humans, Siberia,

    Abstract: Northwest Siberia is geographically remote territory, which has been settled by indigenous human populations probably since the Upper Paleolithic. To investigate the genetic landscape of Northwest Siberians, we have analyzed mitochondrial and Y chromosome DNA polymorphisms of 169 unrelated individuals from Khanty and Mansi ethnic groups in Northwest Siberia. In addition, HVS-I sequences (N = 3522) and Y chromosome SNP data (N = 2175), obtained from the literature, were used to elucidate the genetic relationships among the North Eurasian populations. The results show clinal distributions of mtDNA and Y chromosome haplogroups along East-West axis of Northern Eurasia. In this context, the Ugric-speaking Khanty and Mansi appear as unique intermediate populations carrying Upper Paleolithic and more recent haplotypes typical for both West and East Eurasian gene pools. This admixture indicates that the Khanty and Mansi populations have resided in the contact zone of genetically distinguishable eastern and western Eurasia.

    Notes: Pimenoff, Ville N, Comas, David, Palo, Jukka U, Vershubsky, Galina, Kozlov, Andrew, Sajantila, Antti, Research Support, Non-U.S. Gov't, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2008 Oct;16(10):1254-64. Epub 2008 May 28.,

    Author Address: Department of Forensic Medicine, Laboratory of Forensic Biology, University of Helsinki, Helsinki, Finland.

    Language: eng