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Reference Type: Journal Article
Record Number: 123
Author: V. N. Pimenoff, D. Comas, J. U. Palo, G. Vershubsky, A. Kozlov and A. Sajantila
Year: 2008
Title: Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers
Journal: Eur J Hum Genet
Volume: 16
Issue: 10
Pages: 1254-64
Epub Date: 2008/05/29
Date: Oct
Short Title: Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers
ISSN: 1018-4813 (Print)
DOI: ejhg2008101 [pii], 10.1038/ejhg.2008.101,
Accession Number: 18506205
Keywords: Chromosomes, Human, Y/genetics, DNA, Mitochondrial/genetics, Ethnic Groups/*genetics, *Gene Pool, Genealogy and Heraldry, Genetic Markers, Genetic Variation, Haplotypes, Humans, Siberia,
Abstract: Northwest Siberia is geographically remote territory, which has been settled by indigenous human populations probably since the Upper Paleolithic. To investigate the genetic landscape of Northwest Siberians, we have analyzed mitochondrial and Y chromosome DNA polymorphisms of 169 unrelated individuals from Khanty and Mansi ethnic groups in Northwest Siberia. In addition, HVS-I sequences (N = 3522) and Y chromosome SNP data (N = 2175), obtained from the literature, were used to elucidate the genetic relationships among the North Eurasian populations. The results show clinal distributions of mtDNA and Y chromosome haplogroups along East-West axis of Northern Eurasia. In this context, the Ugric-speaking Khanty and Mansi appear as unique intermediate populations carrying Upper Paleolithic and more recent haplotypes typical for both West and East Eurasian gene pools. This admixture indicates that the Khanty and Mansi populations have resided in the contact zone of genetically distinguishable eastern and western Eurasia.
Notes: Pimenoff, Ville N, Comas, David, Palo, Jukka U, Vershubsky, Galina, Kozlov, Andrew, Sajantila, Antti, Research Support, Non-U.S. Gov't, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2008 Oct;16(10):1254-64. Epub 2008 May 28.,
Author Address: Department of Forensic Medicine, Laboratory of Forensic Biology, University of Helsinki, Helsinki, Finland.
Language: eng
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