Reference Type: Journal Article

Record Number: 129

Author: C. Robino, F. Crobu, C. Di Gaetano, A. Bekada, S. Benhamamouch, N. Cerutti, A. Piazza, S. Inturri and C. Torre

Year: 2008

Title: Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample

Journal: Int J Legal Med

Volume: 122

Issue: 3

Pages: 251-5

Epub Date: 2007/10/03

Date: May

Short Title: Analysis of Y-chromosomal SNP haplogroups and STR haplotypes in an Algerian population sample

ISSN: 0937-9827 (Print)

DOI: 10.1007/s00414-007-0203-5,

Accession Number: 17909833

Keywords: Algeria, Arabs/genetics, *Chromosomes, Human, Y, DNA Fingerprinting, Gene Frequency, *Genetics, Population, *Haplotypes, Humans, Male, Polymerase Chain Reaction, *Polymorphism, Single Nucleotide, *Tandem Repeat Sequences,

Abstract: The distribution of Y-chromosomal single nucleotide polymorphism (SNP) haplogroups and short tandem repeat (STR) haplotypes was determined in a sample of 102 unrelated men of Arab origin from northwestern Algeria (Oran area). A total of nine different haplogroups were identified by a panel of 22 binary markers. The most common haplogroups observed in the Algerian population were E3b2 (45.1%) and J1 (22.5%). Y-STR typing by a 17-loci multiplex system allowed 93 haplotypes to be defined (88 were unique). Striking differences in the allele distribution and gene diversity of Y-STR markers between haplogroups could be found. In particular, intermediate alleles at locus DYS458 specifically characterized the haplotypes of individuals carrying haplogroup J1. All the intermediate alleles shared a common repeat sequence structure, supporting the hypothesis that the variant originated from a single mutational event.

Notes: Robino, C, Crobu, F, Di Gaetano, C, Bekada, A, Benhamamouch, S, Cerutti, N, Piazza, A, Inturri, S, Torre, C, Research Support, Non-U.S. Gov't, Germany, International journal of legal medicine, Int J Legal Med. 2008 May;122(3):251-5. Epub 2007 Oct 2.,

Author Address: Department of Anatomy, Pharmacology and Legal Medicine, University of Turin, Turin, Italy. carlo.robino@unito.it

Language: eng