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    High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males


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    Reference Type: Journal Article

    Record Number: 137

    Author: J. J. Sanchez, C. Hallenberg, C. Borsting, A. Hernandez and N. Morling

    Year: 2005

    Title: High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males

    Journal: Eur J Hum Genet

    Volume: 13

    Issue: 7

    Pages: 856-66

    Epub Date: 2005/03/10

    Date: Jul

    Short Title: High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males

    ISSN: 1018-4813 (Print)

    DOI: 5201390 [pii], 10.1038/sj.ejhg.5201390,

    Accession Number: 15756297

    Keywords: Chromosomes, Human, Y/*genetics, *Gene Frequency, *Genetic Markers, Genetic Variation, *Genetics, Population, Haplotypes/genetics, Humans, Male, Somalia, Turkey,

    Abstract: We genotyped 45 biallelic markers and 11 STR systems on the Y chromosome in 201 male Somalis. In addition, 65 sub-Saharan Western Africans, 59 Turks and 64 Iraqis were typed for the biallelic Y chromosome markers. In Somalis, 14 Y chromosome haplogroups were identified including E3b1 (77.6%) and K2 (10.4%). The haplogroup E3b1 with the rare DYS19-11 allele (also called the E3b1 cluster gamma) was found in 75.1% of male Somalis, and 70.6% of Somali Y chromosomes were E3b1, DYS19-11, DYS392-12, DYS437-14, DYS438-11 and DYS393-13. The haplotype diversity of eight Y-STRs ('minimal haplotype') was 0.9575 compared to an average of 0.9974 and 0.9996 in European and Asian populations. In sub-Saharan Western Africans, only four haplogroups were identified. The West African clade E3a was found in 89.2% of the samples and the haplogroup E3b1 was not observed. In Turks, 12 haplogroups were found including J2*(xJ2f2) (27.1%), R1b3*(xR1b3d, R1b3f) (20.3%), E3b3 and R1a1*(xR1a1b) (both 11.9%). In Iraqis, 12 haplogroups were identified including J2*(xJ2f2) (29.7%) and J*(xJ2) (26.6%). The data suggest that the male Somali population is a branch of the East African population - closely related to the Oromos in Ethiopia and North Kenya - with predominant E3b1 cluster gamma lineages that were introduced into the Somali population 4000-5000 years ago, and that the Somali male population has approximately 15% Y chromosomes from Eurasia and approximately 5% from sub-Saharan Africa.

    Notes: Sanchez, Juan J, Hallenberg, Charlotte, Borsting, Claus, Hernandez, Alexis, Morling, Niels, Research Support, Non-U.S. Gov't, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2005 Jul;13(7):856-66.,

    Author Address: Department of Forensic Genetics, Institute of Forensic Medicine, University of Copenhagen, Denmark. juan.sanchez@forensic.ku.dk

    Language: eng