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    Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists


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    Reference Type: Journal Article

    Record Number: 141

    Author: S. Sengupta, L. A. Zhivotovsky, R. King, S. Q. Mehdi, C. A. Edmonds, C. E. Chow, A. A. Lin, M. Mitra, S. K. Sil, A. Ramesh, M. V. Usha Rani, C. M. Thakur, L. L. Cavalli-Sforza, P. P. Majumder and P. A. Underhill

    Year: 2006

    Title: Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists

    Journal: Am J Hum Genet

    Volume: 78

    Issue: 2

    Pages: 202-21

    Epub Date: 2006/01/10

    Date: Feb

    Short Title: Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists

    ISSN: 0002-9297 (Print)

    DOI: S0002-9297(07)62353-2 [pii], 10.1086/499411,

    Accession Number: 16400607

    Keywords: Asia, Central/ethnology, Asian Continental Ancestry Group/genetics, Chromosomes, Human, Y/*genetics, Genetic Markers, *Genetic Variation, Haploidy, Humans, India/ethnology, *Language, Male, Microsatellite Repeats, *Phylogeny,

    Abstract: Although considerable cultural impact on social hierarchy and language in South Asia is attributable to the arrival of nomadic Central Asian pastoralists, genetic data (mitochondrial and Y chromosomal) have yielded dramatically conflicting inferences on the genetic origins of tribes and castes of South Asia. We sought to resolve this conflict, using high-resolution data on 69 informative Y-chromosome binary markers and 10 microsatellite markers from a large set of geographically, socially, and linguistically representative ethnic groups of South Asia. We found that the influence of Central Asia on the pre-existing gene pool was minor. The ages of accumulated microsatellite variation in the majority of Indian haplogroups exceed 10,000-15,000 years, which attests to the antiquity of regional differentiation. Therefore, our data do not support models that invoke a pronounced recent genetic input from Central Asia to explain the observed genetic variation in South Asia. R1a1 and R2 haplogroups indicate demographic complexity that is inconsistent with a recent single history. Associated microsatellite analyses of the high-frequency R1a1 haplogroup chromosomes indicate independent recent histories of the Indus Valley and the peninsular Indian region. Our data are also more consistent with a peninsular origin of Dravidian speakers than a source with proximity to the Indus and with significant genetic input resulting from demic diffusion associated with agriculture. Our results underscore the importance of marker ascertainment for distinguishing phylogenetic terminal branches from basal nodes when attributing ancestral composition and temporality to either indigenous or exogenous sources. Our reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape.

    Notes: Sengupta, Sanghamitra, Zhivotovsky, Lev A, King, Roy, Mehdi, S Q, Edmonds, Christopher A, Chow, Cheryl-Emiliane T, Lin, Alice A, Mitra, Mitashree, Sil, Samir K, Ramesh, A, Usha Rani, M V, Thakur, Chitra M, Cavalli-Sforza, L Luca, Majumder, Partha P, Underhill, Peter A, Research Support, Non-U.S. Gov't, United States, American journal of human genetics, Am J Hum Genet. 2006 Feb;78(2):202-21. Epub 2005 Dec 16.,

    Author Address: Human Genetics Unit, Indian Statistical Institute, Kolkata, India.

    Language: eng