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    Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans


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    Reference Type: Journal Article

    Record Number: 158

    Author: B. Wen, X. Xie, S. Gao, H. Li, H. Shi, X. Song, T. Qian, C. Xiao, J. Jin, B. Su, D. Lu, R. Chakraborty and L. Jin

    Year: 2004

    Title: Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans

    Journal: Am J Hum Genet

    Volume: 74

    Issue: 5

    Pages: 856-65

    Epub Date: 2004/03/26

    Date: May

    Short Title: Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans

    ISSN: 0002-9297 (Print)

    DOI: 10.1086/386292, S0002-9297(07)64353-5 [pii],

    Accession Number: 15042512

    Keywords: Chromosomes, Human, Y/*genetics, DNA, Mitochondrial/*genetics, Demography, Emigration and Immigration, Female, Gene Pool, *Genetic Markers, *Genetics, Population, Humans, Male, Myanmar/ethnology, Tibet/ethnology,

    Abstract: An unequal contribution of male and female lineages from parental populations to admixed ones is not uncommon in the American continents, as a consequence of directional gene flow from European men into African and Hispanic Americans in the past several centuries. However, little is known about sex-biased admixture in East Asia, where substantial migrations are recorded. Tibeto-Burman (TB) populations were historically derived from ancient tribes of northwestern China and subsequently moved to the south, where they admixed with the southern natives during the past 2600 years. They are currently extensively distributed in China and Southeast Asia. In this study, we analyze the variations of 965 Y chromosomes and 754 mtDNAs in >20 TB populations from China. By examining the haplotype group distributions of Y-chromosome and mtDNA markers and their principal components, we show that the genetic structure of the extant southern Tibeto-Burman (STB) populations were primarily formed by two parental groups: northern immigrants and native southerners. Furthermore, the admixture has a bias between male and female lineages, with a stronger influence of northern immigrants on the male lineages (approximately 62%) and with the southern natives contributing more extensively to the female lineages (approximately 56%) in the extant STBs. This is the first genetic evidence revealing sex-biased admixture in STB populations, which has genetic, historical, and anthropological implications.

    Notes: Wen, Bo, Xie, Xuanhua, Gao, Song, Li, Hui, Shi, Hong, Song, Xiufeng, Qian, Tingzhi, Xiao, Chunjie, Jin, Jianzhong, Su, Bing, Lu, Daru, Chakraborty, Ranajit, Jin, Li, GM41399/GM/NIGMS NIH HHS/United States, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., United States, American journal of human genetics, Am J Hum Genet. 2004 May;74(5):856-65. Epub 2004 Mar 24.,

    Author Address: State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, Fudan University, Shanghai, China.

    Language: eng