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    Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions

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    Reference Type: Journal Article

    Record Number: 3377

    Author: K. K. Abu-Amero, A. Hellani, A. M. Gonzalez, J. M. Larruga, V. M. Cabrera and P. A. Underhill

    Year: 2009

    Title: Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions

    Journal: BMC Genet

    Volume: 10

    Pages: 59

    Epub Date: 2009/09/24

    Short Title: Saudi Arabian Y-Chromosome diversity and its relationship with nearby regions

    ISSN: 1471-2156 (Electronic)

    DOI: 1471-2156-10-59 [pii], 10.1186/1471-2156-10-59,

    Accession Number: 19772609

    Keywords: African Continental Ancestry Group/*genetics, Chromosomes, Human, Y/*genetics, Emigration and Immigration, Evolution, Molecular, Gene Flow, *Genetics, Population, Geography, Haplotypes, Humans, Male, Polymorphism, Single Nucleotide, Saudi Arabia, Sequence Analysis, DNA,

    Abstract: BACKGROUND: Human origins and migration models proposing the Horn of Africa as a prehistoric exit route to Asia have stimulated molecular genetic studies in the region using uniparental loci. However, from a Y-chromosome perspective, Saudi Arabia, the largest country of the region, has not yet been surveyed. To address this gap, a sample of 157 Saudi males was analyzed at high resolution using 67 Y-chromosome binary markers. In addition, haplotypic diversity for its most prominent J1-M267 lineage was estimated using a set of 17 Y-specific STR loci. RESULTS: Saudi Arabia differentiates from other Arabian Peninsula countries by a higher presence of J2-M172 lineages. It is significantly different from Yemen mainly due to a comparative reduction of sub-Saharan Africa E1-M123 and Levantine J1-M267 male lineages. Around 14% of the Saudi Arabia Y-chromosome pool is typical of African biogeographic ancestry, 17% arrived to the area from the East across Iran, while the remainder 69% could be considered of direct or indirect Levantine ascription. Interestingly, basal E-M96* (n = 2) and J-M304* (n = 3) lineages have been detected, for the first time, in the Arabian Peninsula. Coalescence time for the most prominent J1-M267 haplogroup in Saudi Arabia (11.6 +/- 1.9 ky) is similar to that obtained previously for Yemen (11.3 +/- 2) but significantly older that those estimated for Qatar (7.3 +/- 1.8) and UAE (6.8 +/- 1.5). CONCLUSION: The Y-chromosome genetic structure of the Arabian Peninsula seems to be mainly modulated by geography. The data confirm that this area has mainly been a recipient of gene flow from its African and Asian surrounding areas, probably mainly since the last Glacial maximum onwards. Although rare deep rooting lineages for Y-chromosome haplogroups E and J have been detected, the presence of more basal clades supportive of the southern exit route of modern humans to Eurasian, were not found.

    Notes: Abu-Amero, Khaled K, Hellani, Ali, Gonzalez, Ana M, Larruga, Jose M, Cabrera, Vicente M, Underhill, Peter A, Research Support, Non-U.S. Gov't, England, BMC genetics, BMC Genet. 2009 Sep 22;10:59.,

    Author Address: Molecular Genetics Laboratory, College of Medicine, King Saud University, Riyadh 11411, Saudi Arabia. abuamero@gmail.com

    Language: eng