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    Y-chromosome evidence for differing ancient demographic histories in the Americas

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    Reference Type: Journal Article

    Record Number: 5665

    Author: M. C. Bortolini, F. M. Salzano, M. G. Thomas, S. Stuart, S. P. Nasanen, C. H. Bau, M. H. Hutz, Z. Layrisse, M. L. Petzl-Erler, L. T. Tsuneto, K. Hill, A. M. Hurtado, D. Castro-de-Guerra, M. M. Torres, H. Groot, R. Michalski, P. Nymadawa, G. Bedoya, N. Bradman, D. Labuda and A. Ruiz-Linares

    Year: 2003

    Title: Y-chromosome evidence for differing ancient demographic histories in the Americas

    Journal: Am J Hum Genet

    Volume: 73

    Issue: 3

    Pages: 524-39

    Epub Date: 2003/08/06

    Date: Sep

    Short Title: Y-chromosome evidence for differing ancient demographic histories in the Americas

    ISSN: 0002-9297 (Print)

    DOI: 10.1086/377588, S0002-9297(07)62016-3 [pii],

    Accession Number: 12900798

    Keywords: Asian Continental Ancestry Group/*genetics/history, Canada, *Chromosomes, Human, Y, Emigration and Immigration/*history, Genetic Markers, Genetics, Population/*history, Haplotypes, History, Ancient, Humans, Indians, North American/*genetics/history, Indians, South American/*genetics/history, Male, Microsatellite Repeats, Polymorphism, Genetic, Siberia, South America,

    Abstract: To scrutinize the male ancestry of extant Native American populations, we examined eight biallelic and six microsatellite polymorphisms from the nonrecombining portion of the Y chromosome, in 438 individuals from 24 Native American populations (1 Na Dene and 23 South Amerinds) and in 404 Mongolians. One of the biallelic markers typed is a recently identified mutation (M242) characterizing a novel founder Native American haplogroup. The distribution, relatedness, and diversity of Y lineages in Native Americans indicate a differentiated male ancestry for populations from North and South America, strongly supporting a diverse demographic history for populations from these areas. These data are consistent with the occurrence of two major male migrations from southern/central Siberia to the Americas (with the second migration being restricted to North America) and a shared ancestry in central Asia for some of the initial migrants to Europe and the Americas. The microsatellite diversity and distribution of a Y lineage specific to South America (Q-M19) indicates that certain Amerind populations have been isolated since the initial colonization of the region, suggesting an early onset for tribalization of Native Americans. Age estimates based on Y-chromosome microsatellite diversity place the initial settlement of the American continent at approximately 14,000 years ago, in relative agreement with the age of well-established archaeological evidence.

    Notes: Bortolini, Maria-Catira, Salzano, Francisco M, Thomas, Mark G, Stuart, Steven, Nasanen, Selja P K, Bau, Claiton H D, Hutz, Mara H, Layrisse, Zulay, Petzl-Erler, Maria L, Tsuneto, Luiza T, Hill, Kim, Hurtado, Ana M, Castro-de-Guerra, Dinorah, Torres, Maria M, Groot, Helena, Michalski, Roman, Nymadawa, Pagbajabyn, Bedoya, Gabriel, Bradman, Neil, Labuda, Damian, Ruiz-Linares, Andres, Historical Article, Research Support, Non-U.S. Gov't, United States, American journal of human genetics, Am J Hum Genet. 2003 Sep;73(3):524-39. Epub 2003 Jul 28.,

    Author Address: Department of Biology, University College, London, United Kingdom.

    Language: eng