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    Paternal and maternal lineages in Guinea-Bissau population

    Reference Type: Journal Article

    Record Number: 298

    Author: M. Carvalho, P. Brito, A. M. Bento, V. Gomes, H. Antunes, H. A. Costa, V. Lopes, A. Serra, F. Balsa, L. Andrade, M. J. Anjos, F. Corte-Real and L. Gusmao

    Year: 2011

    Title: Paternal and maternal lineages in Guinea-Bissau population

    Journal: Forensic Sci Int Genet

    Volume: 5

    Issue: 2

    Pages: 114-6

    Epub Date: 2010/11/06

    Date: Mar

    Short Title: Paternal and maternal lineages in Guinea-Bissau population

    ISSN: 1878-0326 (Electronic)

    DOI: S1872-4973(10)00173-0 [pii], 10.1016/j.fsigen.2010.10.007,

    Accession Number: 21051306

    Abstract: The aim of the present work was to study the origin of paternal and maternal lineages in Guinea-Bissau population, inferred by phylogeographic analyses of mtDNA and Y chromosome defined haplogroups. To determine the male lineages present in Guinea-Bissau, 33 unrelated males were typed using a PCR-SNaPshot multiplex based method including 24 Y-SNPs, which characterize the main haplogroups in sub-Saharan Africa and Western Europe. In the same samples, 17 Y-STRs (included in the YFiler kit, Applied Biosystems) were additionally typed. The most frequent lineages observed were E1b1a (xE1b1a4,7)-M2 (68%) and E1a-M33 (15%). The European haplogroup R1b1-P25 was represented with a frequency of 12%. The two hypervariable mtDNA regions were sequenced in 79 unrelated individuals from Guinea-Bissau, and haplogroups were classified based on control region motifs using mtDNA manager. A high diversity of haplogroups was determined in our sample being the most frequent haplogroups characteristic of populations from sub-Saharan Africa, namely L2a1 (15%), L3d (13%), L2c (9%), L3e4 (9%), L0a1 (8%), L1b (6%) and L1c1 (6%). None of the typical European haplogroups (H, J and T) were found in the present sample of Guinea-Bissau. From our results, it is possible to confirm that Guinea-Bissau presents a typically West African profile, marked by a high frequency of the Y chromosome haplogroup E1b1a(xE1b1a4,7)-M2 and a high proportion of mtDNA lineages belonging to the sub-Saharan specific sub-clusters L1 to L3 (89%). A small European influx has been also detected, although restricted to the male lineages.

    Notes: Carvalho, M, Brito, P, Bento, A M, Gomes, V, Antunes, H, Costa, H Afonso, Lopes, V, Serra, A, Balsa, F, Andrade, L, Anjos, M J, Corte-Real, F, Gusmao, L, Research Support, Non-U.S. Gov't, Netherlands, Forensic science international. Genetics, Forensic Sci Int Genet. 2011 Mar;5(2):114-6. Epub 2010 Nov 3.,

    Author Address: Forensic Genetics Service, Centre Branch, National Institute of Legal Medicine IP, Largo da Se Nova, 3000-213 Coimbra, Portugal.

    Language: eng