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    Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture


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    Reference Type: Journal Article

    Record Number: 8339

    Author: G. Chaubey, M. Metspalu, Y. Choi, R. Magi, I. G. Romero, P. Soares, M. van Oven, D. M. Behar, S. Rootsi, G. Hudjashov, C. B. Mallick, M. Karmin, M. Nelis, J. Parik, A. G. Reddy, E. Metspalu, G. van Driem, Y. Xue, C. Tyler-Smith, K. Thangaraj, L. Singh, M. Remm, M. B. Richards, M. M. Lahr, M. Kayser, R. Villems and T. Kivisild

    Year: 2011

    Title: Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture

    Journal: Mol Biol Evol

    Volume: 28

    Issue: 2

    Pages: 1013-24

    Epub Date: 2010/10/28

    Date: Feb

    Short Title: Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture

    ISSN: 1537-1719 (Electronic)

    DOI: msq288 [pii], 10.1093/molbev/msq288,

    Accession Number: 20978040

    Keywords: Asia, Southeastern, Chromosomes, Human, Y, DNA, Mitochondrial/genetics, *Emigration and Immigration, *Genetic Variation, *Genetics, Population, Humans, India, *Language,

    Abstract: The geographic origin and time of dispersal of Austroasiatic (AA) speakers, presently settled in south and southeast Asia, remains disputed. Two rival hypotheses, both assuming a demic component to the language dispersal, have been proposed. The first of these places the origin of Austroasiatic speakers in southeast Asia with a later dispersal to south Asia during the Neolithic, whereas the second hypothesis advocates pre-Neolithic origins and dispersal of this language family from south Asia. To test the two alternative models, this study combines the analysis of uniparentally inherited markers with 610,000 common single nucleotide polymorphism loci from the nuclear genome. Indian AA speakers have high frequencies of Y chromosome haplogroup O2a; our results show that this haplogroup has significantly higher diversity and coalescent time (17-28 thousand years ago) in southeast Asia, strongly supporting the first of the two hypotheses. Nevertheless, the results of principal component and "structure-like" analyses on autosomal loci also show that the population history of AA speakers in India is more complex, being characterized by two ancestral components-one represented in the pattern of Y chromosomal and EDAR results and the other by mitochondrial DNA diversity and genomic structure. We propose that AA speakers in India today are derived from dispersal from southeast Asia, followed by extensive sex-specific admixture with local Indian populations.

    Notes: Chaubey, Gyaneshwer, Metspalu, Mait, Choi, Ying, Magi, Reedik, Romero, Irene Gallego, Soares, Pedro, van Oven, Mannis, Behar, Doron M, Rootsi, Siiri, Hudjashov, Georgi, Mallick, Chandana Basu, Karmin, Monika, Nelis, Mari, Parik, Juri, Reddy, Alla Goverdhana, Metspalu, Ene, van Driem, George, Xue, Yali, Tyler-Smith, Chris, Thangaraj, Kumarasamy, Singh, Lalji, Remm, Maido, Richards, Martin B, Lahr, Marta Mirazon, Kayser, Manfred, Villems, Richard, Kivisild, Toomas, Wellcome Trust/United Kingdom, Research Support, Non-U.S. Gov't, United States, Molecular biology and evolution, Mol Biol Evol. 2011 Feb;28(2):1013-24. Epub 2010 Oct 26.,

    Author Address: Department of Evolutionary Biology, Institute of Molecular and Cell Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia.

    Language: eng