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    The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups


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    Reference Type: Journal Article

    Record Number: 8409

    Author: F. Delfin, J. M. Salvador, G. C. Calacal, H. B. Perdigon, K. A. Tabbada, L. P. Villamor, S. C. Halos, E. Gunnarsdottir, S. Myles, D. A. Hughes, S. Xu, L. Jin, O. Lao, M. Kayser, M. E. Hurles, M. Stoneking and M. C. De Ungria

    Year: 2011

    Title: The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups

    Journal: Eur J Hum Genet

    Volume: 19

    Issue: 2

    Pages: 224-30

    Epub Date: 2010/09/30

    Date: Feb

    Short Title: The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups

    ISSN: 1476-5438 (Electronic)

    DOI: ejhg2010162 [pii], 10.1038/ejhg.2010.162,

    Accession Number: 20877414

    Keywords: African Continental Ancestry Group/*genetics, Asian Continental Ancestry Group/*genetics, Chromosomes, Human, Y/*genetics, Emigration and Immigration, Ethnic Groups/genetics, *Genetic Variation, *Genetics, Population, Haplotypes, Humans, Male, Philippines/ethnology, Population Groups/genetics, Software,

    Abstract: The Philippines exhibits a rich diversity of people, languages, and culture, including so-called 'Negrito' groups that have for long fascinated anthropologists, yet little is known about their genetic diversity. We report here, a survey of Y-chromosome variation in 390 individuals from 16 Filipino ethnolinguistic groups, including six Negrito groups, from across the archipelago. We find extreme diversity in the Y-chromosome lineages of Filipino groups with heterogeneity seen in both Negrito and non-Negrito groups, which does not support a simple dichotomy of Filipino groups as Negrito vs non-Negrito. Filipino non-recombining region of the human Y chromosome lineages reflect a chronology that extends from after the initial colonization of the Asia-Pacific region, to the time frame of the Austronesian expansion. Filipino groups appear to have diverse genetic affinities with different populations in the Asia-Pacific region. In particular, some Negrito groups are associated with indigenous Australians, with a potential time for the association ranging from the initial colonization of the region to more recent (after colonization) times. Overall, our results indicate extensive heterogeneity contributing to a complex genetic history for Filipino groups, with varying roles for migrations from outside the Philippines, genetic drift, and admixture among neighboring groups.

    Notes: Delfin, Frederick, Salvador, Jazelyn M, Calacal, Gayvelline C, Perdigon, Henry B, Tabbada, Kristina A, Villamor, Lilian P, Halos, Saturnina C, Gunnarsdottir, Ellen, Myles, Sean, Hughes, David A, Xu, Shuhua, Jin, Li, Lao, Oscar, Kayser, Manfred, Hurles, Matthew E, Stoneking, Mark, De Ungria, Maria Corazon A, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2011 Feb;19(2):224-30. Epub 2010 Sep 29.,

    Author Address: DNA Analysis Laboratory, Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City, Philippines.

    Language: eng