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    Digging deeper into East African human Y chromosome lineages

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    Reference Type: Journal Article

    Record Number: 6596

    Author: V. Gomes, P. Sanchez-Diz, A. Amorim, A. Carracedo and L. Gusmao

    Year: 2010

    Title: Digging deeper into East African human Y chromosome lineages

    Journal: Hum Genet

    Volume: 127

    Issue: 5

    Pages: 603-13

    Epub Date: 2010/03/10

    Date: Mar

    Short Title: Digging deeper into East African human Y chromosome lineages

    ISSN: 1432-1203 (Electronic)

    DOI: 10.1007/s00439-010-0808-5,

    Accession Number: 20213473

    Keywords: Africa, Eastern, African Continental Ancestry Group/*genetics, *Chromosome Mapping, Chromosomes, Human, Y/*genetics, *Cultural Characteristics, Emigration and Immigration, Ethnic Groups/genetics, Genetics, Population, Haplotypes, Humans, Language, Male, Models, Genetic, Mutation, Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Uganda,

    Abstract: The most significant and widely studied remodeling of the African genetic landscape is the Bantu expansion, which led to an almost total replacement of the previous populations from the sub-Saharan region. However, a poor knowledge exists about other population movements, namely, the Nilotic migration, which is a pastoralist dispersal that, contrary to the Bantu expansion, impacted only East African populations. Here, samples from a Ugandan Nilotic-speaking population were studied for 37 Y chromosome-specific SNPs, and the obtained data were compared with those already available for other sub-Saharan population groups. Although Uganda lies on the fringe of both Bantu and Nilotic expansions, a low admixture with Bantu populations was detected, with haplogroups carrying M13, M182 and M75 mutations prevailing in Nilotes together with a low frequency of the main Bantu haplogroups from clade E1b1a-M2. The results of a comparative analysis with data from other population groups allowed a deeper characterization of some lineages in our sample, clarifying some doubts about the origin of some particular Y-SNPs in different ethnic groups, such as M150, M112 and M75. Moreover, it was also possible to identify a new Y-SNP apparently specific to Nilotic groups, as well as the presence of particular haplogroups that characterize Nilotic populations. The detection of a new haplogroup B2a1b defined by G1, could be, therefore, important to differentiate Nilotes from other groups, helping to trace migration and admixture events that occurred in eastern Africa.

    Notes: Gomes, Veronica, Sanchez-Diz, Paula, Amorim, Antonio, Carracedo, Angel, Gusmao, Leonor, Research Support, Non-U.S. Gov't, Germany, Human genetics, Hum Genet. 2010 Mar;127(5):603-13. Epub 2010 Mar 6.,

    Author Address: Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.

    Language: eng