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    Near eastern neolithic genetic input in a small oasis of the Egyptian Western Desert

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    Reference Type: Journal Article

    Record Number: 168

    Author: M. Kujanova, L. Pereira, V. Fernandes, J. B. Pereira and V. Cerny

    Year: 2009

    Title: Near eastern neolithic genetic input in a small oasis of the Egyptian Western Desert

    Journal: Am J Phys Anthropol

    Volume: 140

    Issue: 2

    Pages: 336-46

    Epub Date: 2009/05/09

    Date: Oct

    Short Title: Near eastern neolithic genetic input in a small oasis of the Egyptian Western Desert

    ISSN: 1096-8644 (Electronic)

    DOI: 10.1002/ajpa.21078,

    Accession Number: 19425100

    Keywords: African Continental Ancestry Group/*genetics, Chromosomes, Human, Y/*chemistry, DNA, Mitochondrial/*chemistry, Egypt, Genetic Variation, *Genetics, Population, Haplotypes, Humans, Male, Phylogeny, Polymorphism, Single Nucleotide,

    Abstract: The Egyptian Western Desert lies on an important geographic intersection between Africa and Asia. Genetic diversity of this region has been shaped, in part, by climatic changes in the Late Pleistocene and Holocene epochs marked by oscillating humid and arid periods. We present here a whole genome analysis of mitochondrial DNA (mtDNA) and high-resolution molecular analysis of nonrecombining Y-chromosomal (NRY) gene pools of a demographically small but autochthonous population from the Egyptian Western Desert oasis el-Hayez. Notwithstanding signs of expected genetic drift, we still found clear genetic evidence of a strong Near Eastern input that can be dated into the Neolithic. This is revealed by high frequencies and high internal variability of several mtDNA lineages from haplogroup T. The whole genome sequencing strategy and molecular dating allowed us to detect the accumulation of local mtDNA diversity to 5,138 +/- 3,633 YBP. Similarly, theY-chromosome gene pool reveals high frequencies of the Near Eastern J1 and the North African E1b1b1b lineages, both generally known to have expanded within North Africa during the Neolithic. These results provide another piece of evidence of the relatively young population history of North Africa.

    Notes: Kujanova, Martina, Pereira, Luisa, Fernandes, Veronica, Pereira, Joana B, Cerny, Viktor, Comparative Study, Research Support, Non-U.S. Gov't, United States, American journal of physical anthropology, Am J Phys Anthropol. 2009 Oct;140(2):336-46.,

    Author Address: Archaeogenetics Laboratory, Institute of Archaeology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.

    Language: eng