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    A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe

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    Reference Type: Journal Article

    Record Number: 3034

    Author: N. M. Myres, S. Rootsi, A. A. Lin, M. Jarve, R. J. King, I. Kutuev, V. M. Cabrera, E. K. Khusnutdinova, A. Pshenichnov, B. Yunusbayev, O. Balanovsky, E. Balanovska, P. Rudan, M. Baldovic, R. J. Herrera, J. Chiaroni, J. Di Cristofaro, R. Villems, T. Kivisild and P. A. Underhill

    Year: 2011

    Title: A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe

    Journal: Eur J Hum Genet

    Volume: 19

    Issue: 1

    Pages: 95-101

    Epub Date: 2010/08/26

    Date: Jan

    Short Title: A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe

    ISSN: 1476-5438 (Electronic)

    DOI: ejhg2010146 [pii], 10.1038/ejhg.2010.146,

    Accession Number: 20736979

    Keywords: Asian Continental Ancestry Group/*genetics, *Biological Evolution, Chromosomes, Human, Y/*genetics, Emigration and Immigration, Europe, European Continental Ancestry Group/*genetics, *Founder Effect, Gene Flow, *Genetics, Population, Haplotypes, Humans, Phylogeny,

    Abstract: The phylogenetic relationships of numerous branches within the core Y-chromosome haplogroup R-M207 support a West Asian origin of haplogroup R1b, its initial differentiation there followed by a rapid spread of one of its sub-clades carrying the M269 mutation to Europe. Here, we present phylogeographically resolved data for 2043 M269-derived Y-chromosomes from 118 West Asian and European populations assessed for the M412 SNP that largely separates the majority of Central and West European R1b lineages from those observed in Eastern Europe, the Circum-Uralic region, the Near East, the Caucasus and Pakistan. Within the M412 dichotomy, the major S116 sub-clade shows a frequency peak in the upper Danube basin and Paris area with declining frequency toward Italy, Iberia, Southern France and British Isles. Although this frequency pattern closely approximates the spread of the Linearbandkeramik (LBK), Neolithic culture, an advent leading to a number of pre-historic cultural developments during the past </=10 thousand years, more complex pre-Neolithic scenarios remain possible for the L23(xM412) components in Southeast Europe and elsewhere.

    Notes: Myres, Natalie M, Rootsi, Siiri, Lin, Alice A, Jarve, Mari, King, Roy J, Kutuev, Ildus, Cabrera, Vicente M, Khusnutdinova, Elza K, Pshenichnov, Andrey, Yunusbayev, Bayazit, Balanovsky, Oleg, Balanovska, Elena, Rudan, Pavao, Baldovic, Marian, Herrera, Rene J, Chiaroni, Jacques, Di Cristofaro, Julie, Villems, Richard, Kivisild, Toomas, Underhill, Peter A, Research Support, Non-U.S. Gov't, England, European journal of human genetics : EJHG, Eur J Hum Genet. 2011 Jan;19(1):95-101. Epub 2010 Aug 25.,

    Author Address: Sorenson Molecular Genealogy Foundation, Salt Lake City, UT, USA.

    Language: eng