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Reference Type: Journal Article
Record Number: 1763
Author: T. S. Simonson, J. Xing, R. Barrett, E. Jerah, P. Loa, Y. Zhang, W. S. Watkins, D. J. Witherspoon, C. D. Huff, S. Woodward, B. Mowry and L. B. Jorde
Title: Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes
Journal: PLoS One
Epub Date: 2011/02/10
Short Title: Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes
ISSN: 1932-6203 (Electronic)
Accession Number: 21305013
Abstract: Humans reached present-day Island Southeast Asia (ISEA) in one of the first major human migrations out of Africa. Population movements in the millennia following this initial settlement are thought to have greatly influenced the genetic makeup of current inhabitants, yet the extent attributed to different events is not clear. Recent studies suggest that south-to-north gene flow largely influenced present-day patterns of genetic variation in Southeast Asian populations and that late Pleistocene and early Holocene migrations from Southeast Asia are responsible for a substantial proportion of ISEA ancestry. Archaeological and linguistic evidence suggests that the ancestors of present-day inhabitants came mainly from north-to-south migrations from Taiwan and throughout ISEA approximately 4,000 years ago. We report a large-scale genetic analysis of human variation in the Iban population from the Malaysian state of Sarawak in northwestern Borneo, located in the center of ISEA. Genome-wide single-nucleotide polymorphism (SNP) markers analyzed here suggest that the Iban exhibit greatest genetic similarity to Indonesian and mainland Southeast Asian populations. The most common non-recombining Y (NRY) and mitochondrial (mt) DNA haplogroups present in the Iban are associated with populations of Southeast Asia. We conclude that migrations from Southeast Asia made a large contribution to Iban ancestry, although evidence of potential gene flow from Taiwan is also seen in uniparentally inherited marker data.
Notes: Simonson, Tatum S, Xing, Jinchuan, Barrett, Robert, Jerah, Edward, Loa, Peter, Zhang, Yuhua, Watkins, W Scott, Witherspoon, David J, Huff, Chad D, Woodward, Scott, Mowry, Bryan, Jorde, Lynn B, GM-59290/GM/NIGMS NIH HHS/United States, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., United States, PloS one, PLoS One. 2011 Jan 31;6(1):e16338.,
Author Address: Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America.